It improves insulin sensitivity and fat metabolism and is often found in combination with GLP-1s in tirzepatides
Ketone bodies prevent mitochondrial permeability and reduce reactive oxygen species (ROS)

Drucker, MD Evidence-based Medicine & Clinical Trials, Hormones, Digestion June 23, 1956 (Montreal, Quebec) MD, University of Toronto (1980) 2026: Governor General's Innovation Awards (GGIA), Rideau Hall Foundation 2025: Fred Conrad Koch Lifetime Achievement Award, Endocrine Society See All Awards Awards & Honours: 2026: Governor General's Innovation Awards (GGIA), Rideau Hall Foundation 2025: Fred Conrad Koch Lifetime Achievement Award, Endocrine Society 2025: Warren Triennial Prize, Massachusetts General Hospital 2025: Breakthrough Prize in Life Sciences, USA 2025: Frontiers of Knowledge Award, BBVA Foundation, Spain 2025: American Association for Cancer Research - Irving Weinstein Foundation Distinguished Lectureship Award 2024: Fred Conrad Koch Lifetime Achievement Award (The Endocrine Society, USA) 2024: Princess of Asturias Award for Scientific Research (Spain) 2023: VinFuture Special Prize for Innovators with Outstanding Achievements in Emerging Fields, Vietnam 2021: Canada Gairdner International Award 2021: Elected to the National Academy of Sciences (USA) 2020: The Warren Alpert Foundation Prize for Biomedical Research 2020: The Transatlantic Medal of the British Endocrine Society 2020: The Endocrine Society John Baxter Award for Entrepreneurship 2019: The Novo Nordisk Foundation EASD Prize for Excellence in Diabetes Research 2019: The Helmholtz Diabetes Centre Lifetime Achievement Award 2019: The Harrison Medal, Australian Endocrine Society 2019: The Harold Hamm International Prize for Diabetes Research 2018: The Manning Foundation Principal Innovation Award 2018: The Canadian Organization for Rare Disorders Scientific Leadership Award 2017: The Harrington Prize for Innovation in Medicine, ASCI and the Harrington Institute 2017: Rolf Luft Award in Endocrinology and Diabetes Research, Karolinska Institute 2015: Rachmiel Levine Award for Scientific Achievement in Diabetes Research, City of Hope, California 2015: Institute of Medical Sciences Graduate Course Lecturer Award, University of Toronto 2015: Elected Fellow of the Royal Society of London, UK 2015: Appointed Officer of the Order of Canada 2014: Manpei Suzuki International Prize for Diabetes Research, Manpei Suzuki Foundation, Tokyo, Japan 2014: Banting Medal for Scientific Achievement, American Diabetes Association 2013: Oon International Award for Preventive Medicine, Cambridge University School of Medicine, United 2012: The Claude Bernard Medal & Lecture, European Association for the Study of Diabetes 2012: Lloyd S.D

When you drink coffee on an empty stomach while taking semaglutide or tirzepatide, the caffeine stimulates gastric acid production and can trigger nausea or stomach upset in some patients, especially during the first few weeks of treatment