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This association has been observed for many years in other clinical studies looking at other methods of tightening blood sugar, but for most people, the risks are manageable by seeing a retina specialist well versed in treating diabetic eye disease
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Activates AMPK (The Metabolic Master Switch) MOTS-C activates AMP-activated protein kinase (AMPK) often called the metabolic master switch. AMPK activation: Increases glucose uptake into cells (improving insulin sensitivity) Enhances fat oxidation (fat burning) Increases mitochondrial biogenesis (creating new, healthy mitochondria) Reduces inflammation Promotes autophagy (cellular cleanup and renewal) This is the same pathway activated by exercise and calorie restriction two of the most powerful interventions for metabolic health and longevity
Funding This work was supported by the Higher Education and Science Committee, Ministry of Education, Science, Culture and Sports of RA (23LCG-3A020 and 26YSMU-CON-S-3A), and YSMU
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