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Use cautiously in patients with diabetes due to potential renal, cardiovascular, and gastrointestinal risks, particularly if dehydration from semaglutide's gastrointestinal effects is present
They also slow down gastric emptying, which moderates the rise in blood glucose levels after meals by delaying the entry of food into the small intestine
Clinical relevance in humans remains uncertain, but semaglutide training for physicians requires discussing this risk during informed consent
FDA-approved peptides are regulated in the same way as other approved drugs
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