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2023 Aug 5;402(10400):472-483.
GLP-1 drugs prompt the pancreas to produce insulin after eating and help control blood sugar levels in people with Type 2 Diabetes, while GLP-1/GIP drugs such as Mounjaro mimic the effects of both insulin and glucagon
This distinction may explain the discrepancy between our findings and those of the recently presented STOP (Semaglutide Treatment Effect On Coronary Atherosclerosis Progression In Diabetes) trial, which assessed non-calcified PV progression via CCTA in 140 T2D patients with chronic atherosclerotic disease and failed to demonstrate the superiority of semaglutide over placebo [31]
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