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Multiple analyses show that when treatment is stopped, most people regain some or all of the weight they lostsometimes moreand that the cardiometabolic benefits do not persist off-drug
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The other is the action of the excipients in stimulating enterocytes to take up material from the extra-cellular fluid by a process of vacuolation
doi:10.1038/srep31166
Approved by the FDA in 1959, it works by stimulating the release of norepinephrine in the hypothalamus, the brain region that regulates hunger and satiety
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