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This is not surprising, considering that tirzepatide and semaglutide evoked more pronounced TBWL and also have glucose-lowering effects by slowing gastric emptying, stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner, independent of their effects on body weight 50,51
Figure S5
If you are losing 0.5 to 1% of body weight per month and experiencing no side effects, the microdose is likely in your therapeutic window
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