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Description

To dissect the role of caspases in the observed profile, we included two inhibitors: Q-VD-OPh (referred to hereafter as QVD), a pan-caspase inhibitor targeting caspases 1, 3, 7, 8, 9, 10 and 12, and Ac-DEVD-CHO (referred to hereafter as DEVD), which selectively inhibits caspases 3, 6, 7, 8 and 10

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Abbreviations BAL: Bronchoalveolar lavage BALF: Bronchoalveolar lavage fluid COPD: chronic obstructive pulmonary disease CS: cigarette smoke CSE: cigarette smoke extract ELF: epithelial lining fluid GSH: glutathione References Pryor WA, Stone K: Oxidants in cigarette smoke

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