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Studies have shown that the regulatory effects of GLP-1RAs on metabolism and inflammatory responses may offer potential benefits for sepsis and associated muscle atrophy (23,59-64)

Identity of microsomal glutathione S-transferases [PMID: 7144747] Laboratory literature summary: Identity of microsomal glutathione S-transferases

Semaglutide is not an FDA-approved treatment for rheumatoid arthritis and should not replace DMARDs or biologics, which are proven to prevent joint damage

This uncertainty may reflect limitations in statistical power, particularly for MR-Egger, which requires stronger assumptions and larger sample sizes to detect causal effects