doi:10.1210/clinem/dgae584 Gofron, K
The use is off-label doctors can prescribe a medicine in a different way than stipulated in its licence if they follow official guidelines as there is little scientific research to show that it works and is safe
At the methodological level, isotope tracing technologies can directly resolve actual metabolic flux changes, single-cell and spatial multi-omics can help identify cell-cell interactions and substrate competition in the tissue microenvironment, and genome-scale metabolic modeling can be used for priority ranking and assessment of targetability
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