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Persistent cloudiness may indicate contamination or degradation
It is extremely easily oxidized to disulfide bonds, forming inactive oxidized glutathione (GSSG)
However, recent evidence also reveals TDP-43 accumulations in the nucleus, not only in the cytoplasm 11,12
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Our findings, which utilize a novel CSMN reporter line with TDP-43 pathology, not only reveal the presence of metabolomic defects at an early stage of the disease, but also suggest that proper modulation of metabolomic imbalance could offer therapeutic strategies to improve the integrity of mitochondria, and thus the health of diseased UMNs
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