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Overexpression of TDP-43 in ALS results in the infiltration of immune cells such as CD 3+ T cells, CD 4+ T cells, and monocytes, along with IgG leakage, activation of EC and pericyte [240, 252, 253]
Storing a vial on its side or inverted keeps the solution in sustained contact with the rubber stopper, which pharmaceutical literature describes as a potential leachable-contamination pathway over extended periods
Hindlimb ischemia model mice were administered with an intraperitoneal injection of rCCL28 (50 g/kg, every four days) or vehicle
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