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For context, NICE guidance on existing approved GLP-1 receptor agonists for example, NICE TA875 (Semaglutide for managing overweight and obesity, 2023) acknowledges GI side effects as a recognised class effect and supports gradual dose escalation to improve tolerability

Measurement of intact GLP-1 is compromised by its concentration below the detection limit of the assay due to its extremely rapid degradation by DPP-IV enzyme ( Notwithstanding the strength of the study, the main limitation includes firstly the T2D population recruited were not all newly diagnosed

You are losing the metabolically active tissue that determines your resting metabolic rate, your functional strength, and your long-term ability to maintain results after discontinuing the medication

Moreover, it's encouraging to see that many individuals who have previously struggled with their weight have found Wegovy to be truly effective