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Unlike full-length growth hormone, AOD-9604 does not stimulate IGF-1 production or interact with traditional growth hormone receptors, indicating an independent mechanism of action that has been the subject of ongoing investigation
KLOW's mechanism as a Klotho mimetic suggests theoretical risks including phosphate dysregulation, hypoglycemia when combined with other glucose-lowering agents, and potential immunogenicity with repeated subcutaneous dosing
doi: 10.1249/01.mss.0000210190.64458.25 85
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