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B12 supports the health of the gastrointestinal tract, helping to maintain proper digestion and absorption processes
Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." These EC50s measure functional potency, not binding affinity
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In the duodenum, pancreatic enzymes break down haptocorrin which allows the pH change to trigger the transfer of B12 to the intrinsic factor (IF) which is a protein made by the stomach
