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Overall, current epidemiologic evidence shows that GLP-1RAs consistently induce fat loss accompanied by proportional lean tissue reduction (Table 1)

Would you say to someone who eats meat and can absorb B12 (which a PA patient cant do because they have no intrinsic factor): Oh you cant eat meat to get your B12 until Monday even though you are B12 deficient on Friday? This is unreasonable

Consequently, the development of therapeutic agents that disrupt various aspects of Gln metabolism may represent a promising anticancer strategy ( Figure 2 )

If gastrointestinal side effects are contributing, dietary modifications such as smaller meals and avoiding reflux triggers may help, though any management should be guided by healthcare professional advice