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10.1038/ng.3314 48 NICE (2022)

In terms of tolerability, GLP-1RAs are commonly associated with GI side effects, which are often dose-dependent and time-limiting [55]

For patients with conditions like lupus , endometriosis , or lipedema , the anti-inflammatory effects combined with weight loss represent a potentially significant quality of life intervention

The model was parameterized as: where CL typ was the typical semaglutide clearance (CL/ F ) for the reference subject, and was used for covariate effect parameters