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This leads to dose-dependent weight loss (typically 8-15% in monotherapy trials), with additive effects when combined with GLP-1 agonists like semaglutide due to complementary mechanisms on energy balance and gastrointestinal function
Unlike other weight-loss medications, GLP-1s mimic a gut-based, appetite-modulating hormone that decreases blood sugar levels and sends signals of fullness to the brain
10.1016/s0895-7061(01)02236-1 86 Esteban-CornejoI.HoF
O'Brien L, Kasti A, Halmos EP, Tuck C, Varney J
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