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Large clinical trials such as LEADER and SUSTAIN-6 have not identified increased fracture risk with GLP-1 therapy compared to placebo
A brainstem circuit for nausea suppression
This is typically mild and triggered by large meals, high-fat foods, or eating too quickly
Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results
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