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For instance, in aortic rings and vascular smooth muscle cells of rat models MMP-2 activates TGF-1 by engaging the SMAD signaling pathway, resulting in the production of the matrix molecules such as fibronectin, and collagen [101]
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Human leukemic cells: receptor binding and biological effects of insulin and insulin-like growth factors
10.1016/j.nbd.2012.08.015 239
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