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Published clinical studies report excellent skin tolerance, with no significant irritation or notable allergic reactions at concentrations used in topical formulations (generally 0.01% to 1%)
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Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist approved by the FDA for type 2 diabetes and chronic weight management
Further, MTX increased the expression of PERK (Figure 6B), GRP78 (Figure 6C), ATF4 (Figure 6D), and CHOP-10 (Figure 6E) in the liver compared to CTRL, indicating that ER stress is implicated in MTX-induced hepatotoxicity
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