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Many people develop lymphedema after surgery that removes lymph nodes

They are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia type 2 (MEN 2), and both carry warnings for pancreatitis, gallbladder disease, and acute kidney injury from dehydration

On one hand, specifically blocking HIF signaling can significantly attenuate hypoxia-driven pathological ROS accumulation