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As an off-target effect, the metabolomics revealed that histidine supplementation reduced and augmented tumoral concentrations of adenosine monophosphate and tryptophan respectively, metabolites associated with immunosuppressive or immunostimulating potential respectively (Supplementary Fig

Alteration in fasting glucose after prolonged treatment with a thiazide diuretic

In parallel, sHSPs, ranging from approximately 12 to 43 kDa, have emerged as critical modulators of protein aggregation and toxicity in the nervous system (Fig