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NHS England rolled out tirzepatide for weight management in cohorts after NICE TA1026 in December 2024: 3 Cohort 1 (from June 2025): adults with a body mass index (BMI) of 40 or higher and at least four of five weight-related conditions (type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease)
Benefits and Risks of Semaglutide Semaglutide is recognized for its efficacy in promoting weight loss
At the 4mg escalation dose, it lasts 2.5 weeks
Potential side effects may include gastrointestinal symptoms such as nausea, vomiting, and constipation
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