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L-carnitine and other trimethylamine (TMA) containing compounds (including GBB and crotonobetaine) can be further metabolized by gut bacteria to yield free TMA (Koeth et al., 2014
The decreased oxygen delivery to tissues and organs causes the tissues not to function correctly, leading to symptoms
S100 calcium binding protein A4 (S100A4) is a critical DAMP that is released upon cell damage or stress and is significantly associated with fibrosis and mediates its effects through TLR4 or AGER
Significant anti-aging and structural changes become apparent at 16-24 weeks
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