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This region-specific action is associated with its local stimulation of hormone-sensitive lipase and enhanced fatty acid oxidation, suggesting potential for site-selective metabolic modulation without systemic hormonal changes

Michelle Andrews, D.C

Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)