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It has been shown that patients with major depressive disorder have systemic and localized disorders of glucose metabolism throughout the course of the disease, disrupting various processes such as glucose uptake, glycoprotein transport, glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation

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however, its subsidiary but important effects of body weight reduction, CVD risk reduction, and pharmacokinetic profiles differ according to the structure-activity relationship (Fig