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Clinical trials are now exploring CDK4/6 inhibitors, EZH2 inhibitors, and immune checkpoint inhibitors in genetically defined subgroups, with early data suggesting potential synergy in tumors with specific epigenetic signatures (Reuss et al., 2020
These differentially expressed genes are likely to be potential targets of caffeine and EGCG in mice with NASH
Ongoing monitoring and nutritional guidance help minimize potential side effects
Similar challenges have been raised in U.S
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