Nausea: This is the most frequently reported symptom, usually occurring when you first start the medication or right after a dose increase
Under normal circumstances, hydrogen sulfide production is balanced by rapid food transit through the digestive tract
Users report enhanced skin quality and faster scar resolution as additional benefits
Additional but rare side effects include: low blood sugar (hypoglycemia) feeling cold unusual muscle pain dizziness slow or irregular heart rate trouble breathing metallic taste changes to nails on fingers and toes Low b12 levels DRUG INTERACTIONS As with other medications, metformin can interact with alcohol and certain medications, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, corticosteroids, hormone replacement therapy and estrogens, oral contraceptives, carbonic anhydrase inhibitors, nifedipine, thiazides or furosemide and other diuretics, phenothiazines, phenytoin, nicotinic acid (niacin), multidrug and toxin extrusion inhibitors, sympathomimetics, calcium channel blockers, isoniazid (antibiotic for tuberculosis), insulin and glyburide or other medications for diabetes, and medications for thyroid disease
