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Tesamorelin contributes sustained GHRH receptor activation, while Ipamorelin engages the ghrelin receptor (GHS-R1a) without significant impact on cortisol, prolactin, or ACTH a selectivity profile of particular interest in metabolic and body composition research
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This regulatory mechanism explains the so-called arginine paradox, which refers to the phenomenon where extracellular L-arginine availability influences NO production despite the saturation of NOS enzymes with intracellular arginine
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