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In addition, in vitro models of primary human adipose stem cells, researchers detected intracellular fat content and quantitative expression of early and mature adipocyte markers (PPAR, FABP4, and HSL), demonstrating that glucagon can significantly reduce adipocyte differentiation, inhibit adipocyte proliferation and adipogenesis

Cifone MG, Alesse E, Di Marzio L, et al

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However, another study demonstrated that the ablation of common adaptors for TLR signaling did not reduce basal IFN-I levels, suggesting the involvement of additional, TLR-independent pathways in maintaining baseline IFN-I production