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Conditions like pernicious anaemia (an autoimmune condition affecting a protein called intrinsic factor vital for B12 absorption), stomach issues (such as from reduced stomach acid or certain medications like proton pump inhibitors), intestinal disorders (like Crohns disease or coeliac disease), or even surgical removal of parts of the small intestine (e.g., gastric bypass surgery) can prevent proper absorption

The rest rely on preclinical data alone

Originally derived from a naturally occurring pineal peptide complex, Epithalon has been investigated for its effects on telomerase activity, circadian rhythm regulation, and oxidative stress resistance in laboratory models

Focus is on laboratory mechanisms and research applications