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Abstract Neurodegenerative diseases are characterized by progressive neuronal dysfunction, often accompanied by chronic inflammatory states and redox imbalance within the central nervous system (CNS)
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TAp73 enhances lactate metabolism through upregulation of PFKL (phosphofructokinase-1, liver type) and serves as a crucial upstream regulator in the mechanisms of lactate accumulation and lactate-associated tumor adaptation, making it an important molecular node linking tumor metabolic reprogramming to lactate accumulation [202]
Fisetin is a senotherapeutic that extends health and lifespan
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