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Another category of substances called antioxidants exist in the cells and can effectively delay or inhibit ROS-induced oxidation

Mild to moderate fat loss

Traditional methods have typically included high performance liquid chromatographic assays and are characterized by underestimation of GSH and overestimation of GSSG due to the autooxidative properties of GSH (Nuhu et al., 2020)

As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner (49, 50) ( Figure 1D )