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It depends on the protocol
It is often referred to as the Curse of the Celts, as it is especially prevalent in people of Celtic and Irish decent
However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)
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