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However, the relationship between GLP-1 therapy, weight loss, and bone health remains complex and context-dependent

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The short duration of action needed to be addressed to exploit the promising effects of GLP- 1 for the development of a clinically beneficial drug

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Based on studies in people with chronic kidney disease (CKD), GLP-1 receptor agonists were shown to be safe (no increased risk for acute kidney injury (AKI) was observed) and efficacious also at lower eGFR ranges [25]

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