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4.2 Oxidative stress mediates metabolic abnormalities in PCOS Oxidative stress is closely related to obesity, IR, and HA in PCOS, and the induced apoptosis of ovarian GCs leads to follicular atresia, which is one of the mechanisms of ovulation disorders in PCOS (150)

Structure of glucagon-like peptide (7-36) amide in a dodecylphosphocholine micelle as determined by 2D NMR

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Moreover, either exendin (939) or GLP-1R siRNA could not eliminate the metformin-induced upregulation of p-PKA protein level in PA-treated endothelial cells (Supplemental Fig