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Dehydration makes most side effects worse
The comparison between phentermine and semaglutide , phentermine and tirzepatide , and phentermine and GLP-1 medications broadly consistently shows the GLP-1 class producing greater weight loss with a more favorable long-term safety profile
GLP1-RAs slow gastric emptying and act directly on the central nervous system to suppress appetite and facilitate weight loss
The maintenance dose of semaglutide is typically between 1 mg to 2 mg once weekly, but it may vary according to the individual's response and treatment goals
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