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Synaptic density declines naturally with age, and Dihexa's mechanism directly targets that loss

also found an upregulation of the autophagy marker protein LC3 downstream of CHAC1, suggesting an autophagy-mediated induction of ferroptosis (Ying et al., 2025)

doi: 10.1017/S0954422418000197 223 BaekeFTakiishiTKorfHGysemansCMathieuC

Read review Dihexa for Autism Spectrum Disorder (ASD) The Campbell rs1858830 MET promoter C-allele autism finding (the strongest mechanistic anchor to Dihexa pharmacology), the January 2026 mGluR5 PET 16-23% lower availability, the December 2025 DAYBUE STIX (trofinetide) Rett approval, the March 2026 FDA leucovorin decision (CFD only, not autism), the 270,701 NHS open referrals breaching NICE NG142, and the ~700,000 UK autistic population