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Western blot analysis was used to measure the expression of GLP-1R in the cartilage tissues of OA, OA + saline and OA + liraglutide groups after the rats induced to develop OA received 28-day treatment with liraglutide or saline

This creates the familiar pattern: weight loss through restriction, biological pushback through increased hunger and cravings, eventual return to previous eating patterns, and weight regain

Incorporating mindfulness and stress reduction techniques can also positively impact gut function

The GLORY trials enrolled exclusively Chinese participants, while the TRIUMPH trials enrolled participants primarily in the United States and Europe