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492 At a concentration of 1 nM, zinc can directly activate RyR2, which has a much higher affinity for zinc than Ca 2+ (about three-fold), providing an essential mechanistic explanation for the association between zinc dyshomeostasis and certain cardiomyopathies
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doi: 10.1016/j.ecoenv.2023.115587 12 JiangLWuQBaoSFanGYangZZhouPet al
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