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The symptoms of vitamin B12 deficiency can be quite debilitating and include, according to scientific research: Chronic fatigue and weakness Shortness of breath Heart palpitations Tingling or numbness in the extremities Poor balance Loss of concentration and poor memory Disorientation Mood changes, including depression Insomnia Imagine trying to maintain a healthy, active lifestyle when you're constantly battling severe fatigue and low energy

Endurance athletes face unique challenges that may increase B12 needs: prolonged training sessions stress the digestive system, potentially impairing absorption, while increased red blood cell turnover demands consistent B12 availability

Silybin inhibits NLRP3 inflammasome assembly through the NAD(+)/SIRT2 pathway in mice [PMID: 28970254] Laboratory literature summary: Silybin inhibits NLRP3 inflammasome assembly through the NAD(+)/SIRT2 pathway in mice with nonalcoholic fatty liver disease

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