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FDA identified particular concern for proposed injectable exposure because no clinical immunogenicity or aggregation studies were available
C1-27 , cisplatin (1 M, dissolved in 0.9% NaCl), PD98059 (10 M), LY294002 (10 M), SP600125 (1 M) or desferoxamine mesylate (10 M) were added alone or in combination and colonies were allowed to grow for 710 days
To find out why, researchers tested the liver cells to see what had changed in the depressed mice
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