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Clinical Significance Semaglutides impact on the location of fat loss is significant for more than cosmetic reasons
However, there is still an unmet need for treatment, and there are still some patients who have not achieved MMS, which illustrates the dilemma of MG treatment
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In the SURMOUNT-4 trial, tirzepatide achieved weight reductions of up to 22.5% at the highest dose, with some subgroups showing even greater loss compared to semaglutide alone
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