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Accumulating evidence suggests that gut microbiota dysbiosis is involved in IBS pathophysiology, with IBS-associated dysbiosis generally characterized by reduced microbial diversity, depletion of protective commensals, and enrichment of symptom-associated taxa [260]

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Franklin ZJ, OHarte FPM, Irwin N (2014) Effects of short-term chemical ablation of glucagon signalling by peptide-based glucagon receptor antagonists on insulin secretion and glucose homeostasis in mice