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This research firmly establishes oxidative stress as a shared mechanistic basis for these conditions and underscores the critical need for targeted antioxidant therapies to protect cellular infrastructure
They are the most frequently reported adverse events across every clinical trial conducted to date
More particularly, a strong activation of PKC in the endothelium of diabetic patients is observed in the increased generation of ROS and microvascular OS (Nuez-Musa, 2024), and vasoconstriction potentiates and insulin signaling peripherally impairs (Robson et al., 2018)
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