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April 22, 2026
Askari S, Mokhtari S, Shariat SV, Shariati B, Yarahmadi M, Shalbafan M
Step 4: Stool softeners and lubricants Docusate sodium (Colace) 100-200 mg twice daily Mineral oil 15-30 mL daily (oral or rectal) Stool softeners are the least effective option for GLP-1 constipation because the primary problem is motility, not stool hardness
Toxin conjugation Glutathione-S-transferase enzymes attach GSH to reactive xenobiotics, marking them for excretion - Phase II liver detoxification
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