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Typical dosages studied for psychiatric or substance-related effects range from 1,000 to 3,000 mg combined EPA + DHA daily, but safety up to 5 g/day has been reported in psychiatric trials, according to a study by Bozzatello et al
A., Oliver, J
However, the authors noted prior evidence from studies like Bezin et al
Functional imaging studies show that GLP-1R agonists blunt neural responses to reward cues in the ventral tegmental area and nucleus accumbens, and retrospective and early prospective data link their use to reduced intake of alcohol and nicotine
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