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"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

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Burns also noted that in 2024, Wegovy, Zepbound, and Ozempic had nearly half a billion dollars in advertising behind them, and asked a fair question: if these drugs work so well, why the need to market them so aggressively