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Following ligand binding, activation of the Epac/PI3K/Akt signaling axis promotes mitochondrial biogenesis, enhances insulin sensitivity, and suppresses apoptotic signaling, thereby supporting cellular energy homeostasis
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"SURMOUNT-1: Tirzepatide Once Weekly for the Treatment of Obesity." ACC.org Wilding JPH, et al
Accessed 20 Nov 2021 Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
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