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Both pharmacological inhibition and partial deletion of endothelial PFKFB3 reduced tumor vascularization and metastasis, while also increasing vessel stability, which aided drug delivery and enhanced the effect of chemotherapy in a murine liver cancer model (132)
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Pyridostigmine should be started (oral tablets) at least several hours before exposure to soman (8 hours in advance is preferred) , and discontinued upon exposure to the nerve gas, at which point atropine and pralidoxime are given at the first indication of exposure (see video in Figure 4)
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